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Literature summary for 3.1.4.39 extracted from

  • Ferry, G.; Giganti, A.; Coge, F.; Bertaux, F.; Thiam, K.; Boutin, J.A.
    Functional invalidation of the autotaxin gene by a single amino acid mutation in mouse is lethal (2007), FEBS Lett., 581, 3572-3578.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cloned from 129S6/Sv mouse brain, expression in COS-7 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
DELTA202-363 COS cells transfected with mutated ATX express catalytically inactive phosphodiesterase and lysophospholipase D. Lethality of the ATX-/-embryos. ATX-dependent LPA production is due to the catalytic activity of the enzyme Mus musculus
T210A inactive enzyme, generation of a mouse line displaying an inactivated ATX gene product. Lethality of the ATX-/-embryos. ATX-dependent LPA production is due to the catalytic activity of the enzyme. Clone identified, by both PCR and Southern blot as targeted at the Atx locus Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lyso-phosphatidylcholine + H2O
-
Mus musculus lyso-phosphatidic acid + choline central in some key metabolic deregulations ?

Synonyms

Synonyms Comment Organism
autotaxin member of the phosphodiesterase family of enzymes Mus musculus
lysophospholipase D
-
Mus musculus