Cloned (Comment) | Organism |
---|---|
cloned from 129S6/Sv mouse brain, expression in COS-7 cells | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
DELTA202-363 | COS cells transfected with mutated ATX express catalytically inactive phosphodiesterase and lysophospholipase D. Lethality of the ATX-/-embryos. ATX-dependent LPA production is due to the catalytic activity of the enzyme | Mus musculus |
T210A | inactive enzyme, generation of a mouse line displaying an inactivated ATX gene product. Lethality of the ATX-/-embryos. ATX-dependent LPA production is due to the catalytic activity of the enzyme. Clone identified, by both PCR and Southern blot as targeted at the Atx locus | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
lyso-phosphatidylcholine + H2O | - |
Mus musculus | lyso-phosphatidic acid + choline | central in some key metabolic deregulations | ? |
Synonyms | Comment | Organism |
---|---|---|
autotaxin | member of the phosphodiesterase family of enzymes | Mus musculus |
lysophospholipase D | - |
Mus musculus |