Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme knockdown by siRNA knockdown of CNPase in BV-2 cells | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Rattus norvegicus Sprague-Dawley | - |
- |
- |
Rattus norvegicus Wistar | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amoeboid microglial cell | - |
Rattus norvegicus | - |
brain | amoeboid microglial cells in the postnatal rat brain | Rattus norvegicus | - |
BV-2 cell | - |
Mus musculus | - |
microglia | - |
Mus musculus | - |
microglia | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
2',3'-cyclic nucleotide 3'-phosphodiesterase | - |
Mus musculus |
2',3'-cyclic nucleotide 3'-phosphodiesterase | - |
Rattus norvegicus |
CNPase | - |
Mus musculus |
CNPase | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | markedly enhanced enzyme expression, CNPase protein and mRNA expression, in microglia after activation by lipopolysaccharide treatment | up |
Rattus norvegicus | markedly enhanced enzyme expression, CNPase protein and mRNA expression, in microglia after activation by lipopolysaccharide treatment | up |
General Information | Comment | Organism |
---|---|---|
malfunction | inducible nitric oxide synthase, IL-1beta, TNF-alpha, reactive oxygen species and nitric oxide are significantly upregulated in activated BV-2 cells with CNPase enzyme knockdown. siRNA knockdown of the enzyme increases microglia migration, on the other hand, microglial cells appear to be arrested at G1 phase | Mus musculus |
physiological function | the enzyme encoding gene may play an important role as a putative anti-inflammatory gene both in normal and injured brain | Mus musculus |
physiological function | the enzyme encoding gene may play an important role as a putative anti-inflammatory gene both in normal and injured brain | Rattus norvegicus |