Cloned (Comment) | Organism |
---|---|
GC-CNP encoding 155238 aa of GFP fused to the N-terminus of CNP co-transfected with YN-Ub into COS-7 cells | Chlorocebus aethiops |
GC-CNP encoding 155238 aa of GFP fused to the N-terminus of CNP co-transfected with YN-Ub into MO3.13 cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | partially localize within lipid rafts | Homo sapiens | - |
- |
additional information | partially localize within lipid rafts | Chlorocebus aethiops | - |
- |
additional information | ubiquitinated CNP in the Triton X-100 insoluble lipid raft associated fractions of myelin | Macaca mulatta | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
in lipid raft fraction from an aged monkey, evidence of sequential CNP proteolysis, abundance of CNP immunoreactive higher molecular weight material | Macaca mulatta |
40000 | - |
2D electrophoresis and immunoblotting, lipid raft fraction from a young monkey | Macaca mulatta |
46000 | - |
endogenous CNP, immunoblot analysis | Homo sapiens |
48000 | - |
endogenous CNP, immunoblot analysis | Homo sapiens |
50000 | - |
2D electrophoresis and immunoblotting, lipid raft fraction from a young monkey | Macaca mulatta |
50000 | - |
GC-CNP transfected MO3.13 cells, immunoblot analysis | Homo sapiens |
60000 | - |
GC-CNP transfected MO3.13 cells, immunoblot analysis | Homo sapiens |
150000 | - |
GC-CNP/YN-Ub complex transfected MO3.13 cells, immunoblot analysis | Homo sapiens |
250000 | - |
GC-CNP/YN-Ub complex transfected MO3.13 cells, immunoblot analysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chlorocebus aethiops | - |
- |
- |
Homo sapiens | - |
- |
- |
Macaca mulatta | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Macaca mulatta | - |
cerebral white matter | with age, CNP accumulates throughout brain white matter accompanied by proteolytic fragments of CNP. Equal increase in both isoforms CNP1 and CNP2 | Macaca mulatta | - |
COS-7 cell | ubiquitinated CNP | Chlorocebus aethiops | - |
additional information | MO3.13 cell, ubiquitinated CNP | Homo sapiens | - |
myelin | with age, CNP accumulates in myelin accompanied by proteolytic fragments of CNP. Equal increase in both isoforms CNP1 and CNP2 | Macaca mulatta | - |
oligodendrocyte | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
2',3'-cyclic nucleotide 3'-phosphodiesterase | - |
Homo sapiens |
2',3'-cyclic nucleotide 3'-phosphodiesterase | - |
Macaca mulatta |
2',3'-cyclic nucleotide 3'-phosphodiesterase | - |
Chlorocebus aethiops |
CNP | - |
Homo sapiens |
CNP | - |
Macaca mulatta |
CNP | - |
Chlorocebus aethiops |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Macaca mulatta | 2D electrophoresis and immunoblotting, lipid raft fraction from a young monkey | - |
9 |
Organism | Comment | Expression |
---|---|---|
Macaca mulatta | CNP mRNA levels do not change with age | additional information |
General Information | Comment | Organism |
---|---|---|
physiological function | an age-related impairment in proteasomal proteolysis and subsequent accumulation of ubiquitinated CNP activates alternative proteolytic mechanisms leading to CNP fragmentation | Chlorocebus aethiops |
physiological function | an age-related impairment in proteasomal proteolysis and subsequent accumulation of ubiquitinated CNP activates alternative proteolytic mechanisms leading to CNP fragmentation. In the aged monkey, CNP is ubiquitinated and this ubiquitination can be found (at least in part) in detergent insoluble membrane microdomains | Homo sapiens |
physiological function | incomplete degradation of CNP due to failure of the proteasomal system and aberrant degradation by calpain-1 leads to agerelated CNP accumulation and proteolysis. These phenomena result in age-related dysfunction of CNP in the lipid raft, which may lead to myelin and axonal pathology | Macaca mulatta |