Literature summary for 3.1.4.37 extracted from

Stingo, S.; Masullo, M.; Polverini, E.; Laezza, C.; Ruggiero, I.; Arcone, R.; Ruozi, E.; Dal Piaz, F.; Malfitano, A.M.; DUrsi, A.M.; Bifulco, M.
The N-terminal domain of 2,3-cyclic nucleotide 3-phosphodiesterase harbors a GTP/ATP binding site (2007), Chem. Biol. Drug Des., 70, 502-510.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression with His-tag	Rattus norvegicus

Crystallization (Commentary)

Crystallization (Comment)	Organism
modeling of enzyme N-terminal region and simulation of docking of nucleotides	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme binds purine nucleotide triphosphates with an affinity higher than that displayed for diphosphates, while the affinity for both purine monophosphates and pyrimidine nucleotides is negligible. Analysis of binding constants for GTP, GDP, GMP, ATP, ADP, CTP, CDP, UTP, UDP	Rattus norvegicus	?	-	?

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Release 2023.1 (January 2023)