Literature summary for 3.1.4.37 extracted from

Lee, J.; O'Neill, R.C.; Park, M.W.; Gravel, M.; Braun, P.E.
Mitochondrial localization of CNP2 is regulated by phosphorylation of the N-terminal targeting signal by PKC: implications of a mitochondrial function for CNP2 in glial and non-glial cells (2006), Mol. Cell. Neurosci., 31, 446-462.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	enzyme contains a mitochondrial targeting signal at the N-terminus. Import to mitochondria leads to cleavage of signal sequence yielding a mature, truncated form of CNP2 similar in size as CNP1. CNP2 is localized specifically to mitochondria in non-myelinating cells, e.g. in adult liver or embryonic brain. Phosphorylation of the signal sequence by protein kinase C inhibits translocation to mitochondria.	Rattus norvegicus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	isoform CNP2 fused to GFP	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	enzyme contains a mitochondrial targeting signal at the N-terminus. Import to mitochondria leads to cleavage of signal sequence yielding a mature, truncated form of CNP2 similar in size as CNP1. Phosphorylation of the signal sequence by protein kinase C inhibits translocation to mitochondria.	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	embryonic brain	Rattus norvegicus	-
liver	adult liver	Rattus norvegicus	-
myelin	myelinating cell	Rattus norvegicus	-

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Release 2023.1 (January 2023)