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Literature summary for 3.1.4.37 extracted from

  • Gravel, M.; Gao, E.; Hervouet-Zeiber, C.; Parsons, V.; Braun, P.E.
    Transcriptional regulation of 2',3'-cyclic nucleotide 3'-phosphodiesterase gene expression by cyclic AMP in C6 cells (2000), J. Neurochem., 75, 1940-1950.
    View publication on PubMed
Search for more literature for 3.1.4.37

Activating Compound

Activating Compound Comment Organism Structure
additional information up-regulation of CNP1 expression by cAMP or its analogues, e.g. dibutyryl-cAMP, in C6 cells transfected with mouse CNP1 gene Mus musculus
additional information up-regulation of CNP1 expression compared with CMP2 expression by cAMP or its analogues, e.g. dibutyryl-cAMP, in C6 cells Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
CNP gene with various deletions of the CNP promoter, expression in rat C6 cells, regulation of CNP1 promoter activity by cAMP Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information CNP1 promoter deletion and replacement mutants, effect on the stimulatory effect of cAMP on CNP1 gene expression Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information actinomycin D or cycloheximide completely inhibits the dibutyryl-cAMP-induced accumulation of CNP1 mRNA Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46000
-
 x * 46000, CNP1, x * 48000, CNP2 Rattus norvegicus
48000
-
 x * 46000, CNP1, x * 48000, CNP2 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the cAMP-mediated pathway is part of the molecular mechanisms regulating the expression of CNP1 in oligodendrocytes, roles of AP-2, AP-4 and nuclear factor-1 in the regulation of CNP1 expression ?
-
 ?
additional information Rattus norvegicus the cAMP-mediated pathway is part of the molecular mechanisms regulating the expression of CNP1 in oligodendrocytes, roles of AP-2, AP-4, nuclear factor-1 and protein kinase A in the regulation of CNP1 expression ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 2 isoforms: CNP1 and CNP2
-
Rattus norvegicus
-
 2 isoforms: CNP1 and CNP2, encoded by a single gene
-

Source Tissue

Source Tissue Comment Organism Textmining
C6 glioma cell glioma cells Rattus norvegicus
-
oligodendrocyte the two isoforms CNP1 and CNP2 are differentially regulated during the process of maturation, CNP expression pattern Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the cAMP-mediated pathway is part of the molecular mechanisms regulating the expression of CNP1 in oligodendrocytes, roles of AP-2, AP-4 and nuclear factor-1 in the regulation of CNP1 expression Mus musculus ?
-
 ?
additional information the cAMP-mediated pathway is part of the molecular mechanisms regulating the expression of CNP1 in oligodendrocytes, roles of AP-2, AP-4, nuclear factor-1 and protein kinase A in the regulation of CNP1 expression Rattus norvegicus ?
-
 ?
nucleoside 2',3'-cyclic phosphate + H2O
-
 Mus musculus nucleoside 2'-phosphate
-
 ?
nucleoside 2',3'-cyclic phosphate + H2O
-
 Rattus norvegicus nucleoside 2'-phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 46000, CNP1, x * 48000, CNP2 Rattus norvegicus