Literature summary for 3.1.4.35 extracted from

Yamazaki, A.; Bondarenko, V.A.; Matsuura, I.; Tatsumi, M.; Kurono, S.; Komori, N.; Matsumoto, H.; Hayashi, F.; Yamazaki, R.K.; Usukura, J.
Mechanism for the regulation of mammalian cGMP phosphodiesterase6. 1: identification of its inhibitory subunit complexes and their roles (2010), Mol. Cell. Biochem., 339, 215-233.

Search for more literature for 3.1.4.35

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Bos taurus	analysis of diverse complxes formed by subunits Pgamma with GTP or GDP and outer segments, the complexes are extracted from membranes and isolated. Analysis of the function of the single complexes in PDE regulation, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	analysis of diverse complxes formed by subunits Pgamma with GTP or GDP and outer segments, the complexes are extracted from membranes and isolated. Analysis of the function of the single complexes in PDE regulation, overview	Bos taurus	?	-	?

Subunits

Subunits	Comment	Organism
tetramer	alphabeta(gamma)2	Bos taurus

Synonyms

Synonyms	Comment	Organism
cGMP phosphodiesterase6	-	Bos taurus

General Information

General Information	Comment	Organism
physiological function	cyclic GMP phosphodiesterase in bovine rod photoreceptor outer segments comprises a catalytic subunit complex, Palphabeta, and two inhibitory subunits Pgamma, and is regulated by the a subunit of transducin. The mechanism for PDE regulation involves complex formations between the gamma subunits with outer segments, overview. Pgamma as a complex with the GTP-bound transducin a subunit, GTP-Talpha, dissociates from Palphabetagammagamma on membranes, and the Palphabetagammagamma becomes Pgamma-depleted	Bos taurus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)