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Literature summary for 3.1.4.35 extracted from

  • Tosi, J.; Davis, R.J.; Wang, N.K.; Naumann, M.; Lin, C.S.; Tsang, S.H.
    shRNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosa (2011), J. Cell. Mol. Med., 15, 1778-1787.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.35

Activating Compound

Activating Compound Comment Organism Structure
light light stimulates PDE6 activation, rapid reduction in cGMP, closure of Na+/Ca2+ channels and reduced Ca2+ influx Mus musculus

Protein Variants

Protein Variants Comment Organism
H620Q generation of Pde6bH620Q mice as mouse model, knockdown of guanylate cyclase and cGMP-gated Na+/Ca2+ channels, phenotype compared to control C57BL/6J mice, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
sildenafil
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57/BL6J
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
photoreceptor cell
-
 Mus musculus
-
retina
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
cGMP phosphodiesterase
-
 Mus musculus
PDE6
-
 Mus musculus
PDE6B
-
 Mus musculus

General Information

General Information Comment Organism
metabolism during rod phototransduction, cGMP and Ca2+ are regulated by PDE6, guanylate cyclase, and cGMP-gated Na+/Ca2+ channels. The level of cGMP is controlled by opposing activities of PDE6 and guanylate cyclase and, at sufficiently high levels, Na+/Ca2+ channels open to allow increased Ca2+ influx into the rod outer segment Mus musculus