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Literature summary for 3.1.4.35 extracted from

  • Tsang, S.H.; Woodruff, M.L.; Lin, C.S.; Jacobson, B.D.; Naumann, M.C.; Hsu, C.W.; Davis, R.J.; Cilluffo, M.C.; Chen, J.; Fain, G.L.
    Effect of the ILE86TER mutation in the gamma subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signaling (2011), Cell. Signal., 24, 181-188.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information introduction of a modified Pde6g gene for PDE6gamma into a line of Pde6gtm1/Pde6gtm1 mice that do not express PDE6gamma. The resulting ILE86TER mutant mice have a PDE6gamma that lacks the two final carboxyl-terminal Ile86 and Ile87 residues, a mutation that reduces inhibition by PDE6gamma. ILE86TER rods show a decreased sensitivity and rate of activation, and a decreased rate of decay of the photoresponse, consistent with decreased inhibition of PDE6 alpha and beta by PDE6gamma. ILE86TER mutant rods have a higher rate of spontaneous activation of PDE6 than wild-type rods Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
3-isobutyl-1-methylxanthine IBMX, a PDE6 inhibitor Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
eye rod outer segment Mus musculus
-

Subunits

Subunits Comment Organism
tetramer alphabeta(gamma)2,PDE6 consistis of catalytic alpha and beta subunits and two inhibitory gamma subunits Mus musculus

Synonyms

Synonyms Comment Organism
cGMP phosphodiesterase
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Mus musculus
PDE6
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Mus musculus

General Information

General Information Comment Organism
physiological function PDE6 consistis of catalytic alpha and beta subunits and two inhibitory gamma subunits, molecular mechanism of PDE6gamma regulation of the catalytic subunits, overview. Ile86 and Ile87 residues are necessary for normal inhibition of PDE6 catalytic activity in vivo, and increased basal activity of PDE can be partially compensated by GCAP-dependent regulation of guanylyl cyclase Mus musculus