Literature summary for 3.1.4.35 extracted from

Pifarre, P.; Prado, J.; Giralt, M.; Molinero, A.; Hidalgo, J.; Garcia, A.
Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury (2010), J. Neurochem., 112, 807-817.

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Application

Application	Comment	Organism
medicine	peripheral administration of the cGMP-PDE inhibitor zaprinast dramatically alters the inflammatory response of astrocytes and microglia/macrophages to focal brain injury, decreases oxidative stress and neurodegeneration, and increases angiogenesis and vascular endothelial growth factor expression	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
zaprinast	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3',5'-cGMP + H2O	Rattus norvegicus	-	5'-GMP	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3',5'-cGMP + H2O	-	Rattus norvegicus	5'-GMP	-	?

Synonyms

Synonyms	Comment	Organism
cGMP phosphodiesterase	-	Rattus norvegicus
cGMP-PDE	-	Rattus norvegicus
PDE5	-	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00013	-	pH and temperature not specified in the publication	Rattus norvegicus	zaprinast

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Release 2023.1 (January 2023)