Literature summary for 3.1.4.35 extracted from

Iseri, S.O.; Ersoy, Y.; Ercan, F.; Yuksel, M.; Atukeren, P.; Gumustas, K.; Alican, I.
The effect of sildenafil, a phosphodiesterase-5 inhibitor, on acetic acid-induced colonic inflammation in the rat (2009), J. Gastroenterol. Hepatol., 24, 1142-1148.

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Application

Application	Comment	Organism
medicine	5 mg/kg/day sildenafil citrate administration to rats with acetic acid-induced colitis prevents lipid peroxidation, oxidant generation, cytokine production and neutrophil accumulation	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
sildenafil	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3',5'-cGMP + H2O	Rattus norvegicus	-	5'-GMP	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3',5'-cGMP + H2O	-	Rattus norvegicus	5'-GMP	-	?

Synonyms

Synonyms	Comment	Organism
cGMP-specific phosphodiesterase 5	-	Rattus norvegicus
cyclic guanosine monophosphate-specific phosphodiesterase 5	-	Rattus norvegicus
PDE5	-	Rattus norvegicus
phosphodiesterase-5	-	Rattus norvegicus

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Release 2023.1 (January 2023)