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Literature summary for 3.1.4.35 extracted from

  • Sejima, H.; Tominaga, K.; Egawa, T.; Ikeda, M.; Shibuya, K.; Kameyama, N.; Yamauchi, A.; Shuto, H.; Kataoka, Y.
    Gender differences in tail-skin flushing induced by nitrates and phosphodiesterase type 5 inhibitors in a climacteric mouse model (2009), Eur. J. Pharmacol., 624, 66-70.
    View publication on PubMed
Search for more literature for 3.1.4.35

Application

Application Comment Organism
medicine estrogen withdrawal, but not testosterone withdrawal, is a risk factor for PDE5 inhibitor-induced flushing Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
sildenafil
-
 Mus musculus
tadalafil
-
 Mus musculus
vardenafil
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3',5'-cGMP + H2O Mus musculus
-
 5'-GMP
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
artery in the vasculature, PDE5 is the predominant PDE isoform involved in degrading cGMP Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cGMP + H2O
-
 Mus musculus 5'-GMP
-
 ?

Synonyms

Synonyms Comment Organism
PDE5
-
 Mus musculus
phosphodiesterase type 5
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus the expression levels of PDE5 mRNA in the tail artery are significantly decreased in orchidectomized male mice to 31.8% of the levels in sham-operated male mice down