Literature summary for 3.1.4.35 extracted from

Kato, N.; Mashita, Y.; Kato, S.; Mitsufuji, S.; Yoshikawa, T.; Takeuchi, K.
Sildenafil, an inhibitor of phosphodiesterase subtype 5, prevents indomethacin-induced small-intestinal ulceration in rats via a NO/cGMP-dependent mechanism (2009), Digest. Dis. Sci., 54, 2346-2356.

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Application

Application	Comment	Organism
medicine	PDE5 inhibitor sildenafil prevents indomethacin-induced small-intestinal ulceration in rats, via a nitric oxide/cGMP-dependent mechanism	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
sildenafil	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3',5'-cGMP + H2O	Rattus norvegicus	-	5'-GMP	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3',5'-cGMP + H2O	-	Rattus norvegicus	5'-GMP	-	?

Synonyms

Synonyms	Comment	Organism
PDE5	-	Rattus norvegicus
phosphodiesterase subtype 5	-	Rattus norvegicus

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Release 2023.1 (January 2023)