Literature summary for 3.1.4.35 extracted from

Sun, X.Z.; Li, Z.F.; Liu, Y.; Fang, P.; Li, M.X.
Inhibition of cGMP phosphodiesterase 5 suppresses matrix metalloproteinase-2 production in pulmonary artery smooth muscles cells (2010), Clin. Exp. Pharmacol. Physiol., 37, 362-367.

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Application

Application	Comment	Organism
medicine	PDE5 inhibition suppresses RhoA/Rho-associated kinase-mediated MMP-2 production by pulmonary artery smooth muscle cells, which may contribute to the regulation of pulmonary vascular remodelling. Thus, PDE5 inhibition may benefit patients with pulmonary hypertension through multiple mechanisms of action	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
sildenafil	selective PDE5 inhibitor	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pulmonary artery smooth muscle cell	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3',5'-cGMP + H2O	-	Rattus norvegicus	5'-GMP	-	?

Synonyms

Synonyms	Comment	Organism
PDE5	-	Rattus norvegicus
phosphodiesterase 5	-	Rattus norvegicus

General Information

General Information	Comment	Organism
malfunction	inhibition of cGMP phosphodiesterase 5 suppresses matrix metalloproteinase-2 production in pulmonary artery smooth muscle cells	Rattus norvegicus

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Release 2023.1 (January 2023)