Application | Comment | Organism |
---|---|---|
medicine | inhibition of PDE5 decreases pulmonary pressure and improves symptoms in patients with pulmonary arterial hypertension | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sildenafil | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cGMP + H2O | Rattus norvegicus | - |
5'-GMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cGMP + H2O | - |
Rattus norvegicus | 5'-GMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE5 | - |
Rattus norvegicus |
phosphodiesterase 5 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular myocardial remodeling | Rattus norvegicus |