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Literature summary for 3.1.4.35 extracted from
- Contractile agonists attenuate cGMP levels by stimulating phosphorylation of cGMP-specific PDE5; an effect mediated by RhoA/PKC-dependent inhibition of protein phosphatase 1 (2008), Br. J. Pharmacol., 153, 1214-1224.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | phosphodiesterase type 5 inhibitors are considered first-line therapies for men with erectile dysfunction | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| sildenafil | - |
Homo sapiens |  |
| tadalafil | - |
Homo sapiens | |
| vardenafil | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PDE5 | - |
Homo sapiens |
| phosphodiesterase type 5 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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