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Literature summary for 3.1.4.35 extracted from
- Inhibition of human cAMP-phosphodiesterase as a mechanism of the spasmolytic effect of Matricaria recutita L (2008), J. Agric. Food Chem., 56, 5015-5020.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| chamomile | weak, but still statistically significant inhibition of PDE5A1 | Homo sapiens |  |
| sildenafil | 70% inhibition at 100 nM | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3',5'-cGMP + H2O | - |
Homo sapiens | 5'-GMP | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cGMP-PDE | - |
Homo sapiens |
| cGMP-phosphodiesterase | - |
Homo sapiens |
| PDE5A1 | recombinant enzyme | Homo sapiens |
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Release 2023.1 (January 2023)
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