Activating Compound | Comment | Organism | Structure |
---|---|---|---|
alpha-subunit of transducin | in presence of transducin alpha-subunit-GTP, the inhibitory gamma subunit of PDE6 remains attached to the rest of the PDE6 molecule, but after conversion to transducin alpha-subunit-GDP, the PDE6 gamma subunit may dissociate from PDE6 and exchange with a cytoplasmic pool | Mus musculus |
Cloned (Comment) | Organism |
---|---|
overexpression of enzyme gamma subunit in mouse | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of PDE6 gamma subunit in rod photoreceptors decreases the rate of rise of the rod response at dim intensities and also produces a marked acceleration in the falling phase of the light response and more rapid recovery of sensitivity and circulating current after prolonged light exposure | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isoform PDE6 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
retinal rod | rod photoreceptor | Mus musculus | - |
Subunits | Comment | Organism |
---|---|---|
More | binding sites of catalytic subunits alpha and beta of PDE6 are accessible to excess inhibitory subunit gamma in the light, once endogenous gamma subunit has been displaced from its binding site by transducin alpha-subunit-GTP | Mus musculus |