Literature summary for 3.1.4.35 extracted from

Bader, S.; Kortholt, A.; Van Haastert, P.J.
Seven Dictyostelium discoideum phosphodiesterases degrade three pools of cAMP and cGMP (2007), Biochem. J., 402, 153-161.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.005	-	cGMP	isoform PDE5, high affinity form, pH 7.0, 22°C	Dictyostelium discoideum
0.02	-	cGMP	isoform PDE5, low affinity form, pH 7.0, 22°C	Dictyostelium discoideum
0.8	-	cGMP	isoform PDE6, high affinity form, pH 7.0, 22°C	Dictyostelium discoideum
1.6	-	cGMP	isoform PDE6, low affinity form, pH 7.0, 22°C	Dictyostelium discoideum

Organism

Organism	UniProt	Comment	Textmining
Dictyostelium discoideum	-	isoforms PDE5, PDE6	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cGMP + H2O	degradation of intracellular cGMP	Dictyostelium discoideum	5'-GMP	-	?

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Release 2023.1 (January 2023)