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Literature summary for 3.1.4.35 extracted from
- Expression and functional activity of phosphodiesterase type 5 in human and rabbit vas deferens (2005), Mol. Hum. Reprod., 11, 107-115.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| sildenafil | - |
Homo sapiens |  |
| sildenafil | IC50: 7.8 nM | Oryctolagus cuniculus | |
| tadalafil | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | PDE5 gene expression and activity are androgen-dependent in vas deferens | ? | - |
? | |
| additional information | Oryctolagus cuniculus | PDE5 gene expression and activity are androgen-dependent in vas deferens | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| vas deferens | detected in all different muscular layers, as well as endothelial and smooth muscle cells of the blood vessels. No activity in luminal epithelial cells | Homo sapiens | - |
| vas deferens | detected in all different muscular layers, as well as endothelial and smoothmuscle cells of the blood vessels. No activity in luminal epithelial cells | Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | PDE5 gene expression and activity are androgen-dependent in vas deferens | Homo sapiens | ? | - |
? | |
| additional information | PDE5 gene expression and activity are androgen-dependent in vas deferens | Oryctolagus cuniculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PDE5 | - |
Homo sapiens |
| PDE5 | - |
Oryctolagus cuniculus |
| phosphodiesterase 5 | - |
Homo sapiens |
| phosphodiesterase 5 | - |
Oryctolagus cuniculus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000078 | - |
IC50: 7.8 nM | Oryctolagus cuniculus | sildenafil | |
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Release 2023.1 (January 2023)
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