Cloned (Comment) | Organism |
---|---|
catalytic domain (COOH-terminal half-containing the catalytic domain Thr540-Ile949), expression in bacteria | Strongylocentrotus purpuratus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-isobutyl-1-methylxanthine | IC50: 0.032 mM | Strongylocentrotus purpuratus | |
dipyridamole | IC50: 0.023 mM | Strongylocentrotus purpuratus | |
sildenafil | IC50: 0.005 mM | Strongylocentrotus purpuratus | |
T-1032 | IC50: 0.041 mM | Strongylocentrotus purpuratus | |
zaprinast | IC50: 0.24 mM | Strongylocentrotus purpuratus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
3',5'-cGMP | - |
Strongylocentrotus purpuratus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cGMP + H2O | Strongylocentrotus purpuratus | suPDE5 regulates cGMP levels in sperm, which in turn modulate sperm motility | 5'-GMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Strongylocentrotus purpuratus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | suPDE5 activity is regulated by phosphorylation. In vitro dephosphorylation of suPDE5 decreases activity by 50% | Strongylocentrotus purpuratus |
Purification (Comment) | Organism |
---|---|
- |
Strongylocentrotus purpuratus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
sperm flagellum | - |
Strongylocentrotus purpuratus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cGMP + H2O | suPDE5 regulates cGMP levels in sperm, which in turn modulate sperm motility | Strongylocentrotus purpuratus | 5'-GMP | - |
? | |
3',5'-cGMP + H2O | specific for 3',5'-cGMP, no activity with 3',5'-cAMP | Strongylocentrotus purpuratus | 5'-GMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
suPDE5 | - |
Strongylocentrotus purpuratus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | 8 | 3fold increase in activity from pH 7 to pH 8 | Strongylocentrotus purpuratus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.005 | - |
IC50: 0.005 mM | Strongylocentrotus purpuratus | sildenafil | |
0.023 | - |
IC50: 0.023 mM | Strongylocentrotus purpuratus | dipyridamole | |
0.032 | - |
IC50: 0.032 mM | Strongylocentrotus purpuratus | 3-isobutyl-1-methylxanthine | |
0.041 | - |
IC50: 0.041 mM | Strongylocentrotus purpuratus | T-1032 | |
0.24 | - |
IC50: 0.24 mM | Strongylocentrotus purpuratus | zaprinast |