Literature summary for 3.1.4.35 extracted from

Dell'Agli, M.; Galli, G.V.; Vrhovsek, U.; Mattivi, F.; Bosisio, E.
In vitro inhibition of human cGMP-specific phosphodiesterase-5 by polyphenols from red grapes (2005), J. Agric. Food Chem., 53, 1960-1965.

Search for more literature for 3.1.4.35

Cloned(Commentary)

Cloned (Comment)	Organism
expression of isoform PDE5A1 in COS-7 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
delphinidin	-	Homo sapiens
delphinidin 3-glucoside	-	Homo sapiens
malvidin	IC50: 0.0354 mM	Homo sapiens
malvidin-3-O-beta-glucoside	IC50: 0.0116 mM	Homo sapiens
additional information	red wine and extract from grape skin inhibit isoenzyme PDE5A1 activity, seed extract has negligible effect. Polyphenol-induced vasorelexation may be sustained by smooth muscle PDE inhibition by anthocyanins present in red wines and grapes. trans-Resveratrol and trans-piceid exhibit negligible effects. hydroxycinnamates are completely inactive	Homo sapiens
peonidin	-	Homo sapiens
peonidin 3-glucoside	-	Homo sapiens
petunidin	-	Homo sapiens
petunidin 3-glucoside	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
cGMP-specific phosphodiesterase-5	-	Homo sapiens
PDE5A1	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0116	-	IC50: 0.0116 mM	Homo sapiens	malvidin-3-O-beta-glucoside
0.0354	-	IC50: 0.0354 mM	Homo sapiens	malvidin

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)