Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sildenafil | IC50: 49 nM, PDE6 | Bos taurus | |
sildenafil | IC50: 8.5 nM, PDE5; IC50: above 10000 nM, PDE9 | Homo sapiens | |
tadalafil | IC50: 9.4 nM, PDE5; IC50: above 10000 nM, PDE9 | Homo sapiens | |
vardenafil | IC50: 11 nM, PDE6 | Bos taurus | |
vardenafil | IC50: 0.89 nM, PDE5; IC50: 3370 nM, PDE9 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
PDE6 | - |
Bos taurus PDE6 | - |
PDE6 | - |
Homo sapiens | - |
PDE5 | - |
Homo sapiens | - |
PDE9 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | PDE5 | Homo sapiens | - |
brain | PDE5 | Homo sapiens | - |
corpus cavernosum | PDE5 | Homo sapiens | - |
esophagus | PDE5 | Homo sapiens | - |
lung | PDE5 | Homo sapiens | - |
retina | PDE6 | Bos taurus | - |
vascular smooth muscle | PDE5 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | activity with 3',5'-cAMP is higher than with 3',5'-cGMP, PDE6 | Bos taurus | 5'-AMP | - |
? | |
3',5'-cAMP + H2O | activity with 3',5'-cAMP is higher than with 3',5'-cGMP, PDE6 | Bos taurus PDE6 | 5'-AMP | - |
? | |
3',5'-cGMP + H2O | activity with 3',5'-cAMP is higher than with 3',5'-cGMP, PDE6 | Bos taurus | 5'-GMP | - |
? | |
3',5'-cGMP + H2O | selective for 3',5'-cGMP, PDE9 | Homo sapiens | 5'-GMP | - |
? | |
3',5'-cGMP + H2O | specific for 3',5'-cGMP | Homo sapiens | 5'-GMP | - |
? | |
3',5'-cGMP + H2O | activity with 3',5'-cAMP is higher than with 3',5'-cGMP, PDE6 | Bos taurus PDE6 | 5'-GMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PDE5 | - |
Homo sapiens |
PDE6 | - |
Bos taurus |
PDE9 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000089 | - |
IC50: 0.89 nM, PDE5 | Homo sapiens | vardenafil | |
0.0000085 | - |
IC50: 8.5 nM, PDE5 | Homo sapiens | sildenafil | |
0.0000094 | - |
IC50: 9.4 nM, PDE5 | Homo sapiens | tadalafil | |
0.000011 | - |
IC50: 11 nM, PDE6 | Bos taurus | vardenafil | |
0.000049 | - |
IC50: 49 nM, PDE6 | Bos taurus | sildenafil | |
0.00337 | - |
IC50: 3370 nM, PDE9 | Homo sapiens | vardenafil | |
0.01 | - |
IC50: above 10000 nM, PDE9 | Homo sapiens | sildenafil | |
0.01 | - |
IC50: above 10000 nM, PDE9 | Homo sapiens | tadalafil |