Cloned (Comment) | Organism |
---|---|
generation of transgenic animals with targeted expression of DmPDE6 to tubule type I (principal) cells. This reveals localization of DmPDE6 primarily at the apical membranes. Overexpression of DmPDE6 results in elevated cG-PDE activity and decreased tubule cGMP content. Such targeted overexpression of DmPDE6 creates phenotype that manifests itself in inhibition of the active transport and efflux of cGMP by tubules | Drosophila sp. (in: flies) |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
zaprinast | - |
Drosophila sp. (in: flies) |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | generation of transgenic animals with targeted expression of DmPDE6 to tubule type I (principal) cells. This reveals localization of DmPDE6 primarily at the apical membranes | Drosophila sp. (in: flies) | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Drosophila sp. (in: flies) | role for cG-PDE in modulating cGMP transport and efflux | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila sp. (in: flies) | - |
generation of transgenic animals with targeted expression of DmPDE6 to tubule type I (principal) cells. This reveals localization of DmPDE6 primarily at the apical membranes. Overexpression of DmPDE6 results in elevated cG-PDE activity and decreased tubule cGMP content. Such targeted overexpression of DmPDE6 creates a novel phenotype that manifests itself in inhibition of the active transport and efflux of cGMP by tubules | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | role for cG-PDE in modulating cGMP transport and efflux | Drosophila sp. (in: flies) | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cG-PDE | - |
Drosophila sp. (in: flies) |
DmPDE6 | - |
Drosophila sp. (in: flies) |
Drosophila PDE6-like enzyme | - |
Drosophila sp. (in: flies) |