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Literature summary for 3.1.4.35 extracted from

  • Day, J.P.; Dow, J.A.T.; Houslay, M.D.; Davies, S.A.
    Cyclic nucleotide phosphodiesterases in Drosophila melanogaster (2005), Biochem. J., 388, 333-342.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Drosophila S2 cells Drosophila melanogaster

Inhibitors

Inhibitors Comment Organism Structure
sildenafil IC50: IC50: 0.000025 mM Drosophila melanogaster
zaprinast IC50: 0.00065 mM Drosophila melanogaster

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.037
-
 3',5'-cGMP
-
 Drosophila melanogaster

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cGMP + H2O specific for 3',5'-cGMP Drosophila melanogaster 5'-GMP
-
 ?

Synonyms

Synonyms Comment Organism
cG-PDE
-
 Drosophila melanogaster
cGMP-specific PDE
-
 Drosophila melanogaster
PDE6
-
 Drosophila melanogaster

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000025
-
 IC50: 0.000025 mM Drosophila melanogaster sildenafil
0.00065
-
 IC50: 0.00065 mM Drosophila melanogaster zaprinast