Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3-dimethyl-6-(2-propoxy-5-methanesulfonylamidophenyl)pyrazol[3,4d]-pyrimidin-4-(5H)-one | 0.000006 mM, 50% inhibition in sham operated rats | Rattus norvegicus | |
zaprinast | 0.00046 mM, 50% inhibition in sham-operated rats | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanosine 3',5'-cyclic phosphate + H2O | Rattus norvegicus | - |
guanosine 5'-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | inner medullary collecting duct cells | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanosine 3',5'-cyclic phosphate + H2O | - |
Rattus norvegicus | guanosine 5'-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cGMP phosphodiesterase | - |
Rattus norvegicus |
PDE5 | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000045 | - |
1,3-dimethyl-6-(2-propoxy-5-methanesulfonylamidophenyl)pyrazol[3,4d]-pyrimidin-4-(5H)-one | sham-operated rats | Rattus norvegicus | |
0.00031 | - |
zaprinast | sham-operated rats | Rattus norvegicus |