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Literature summary for 3.1.4.35 extracted from

  • O'Grady, S.M.; Jiang, X.; Maniak, P.J.; Birmachu, W.; Scribner, L.R.; Bulbulian, B.; Gullikson, G.W.
    Cyclic AMP-dependent Cl secretion is regulated by multiple phosphodiesterase subtypes in human colonic epithelial cells (2002), J. Membr. Biol., 185, 137-144.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(2Z)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one IC50: 0.00067 mM, PDE5 Homo sapiens
2-[1-(2,4-dichlorobenzyl)-2-methyl-5-(methylmercapto)-1H-indol-3-yl] ethanaminium chloride IC50: 0.002 mM, PDE5 Homo sapiens
Cilostamide IC50: 0.006 mM, PDE5 Homo sapiens
quinazolinamine IC50: 0.000021 mM, PDE5 Homo sapiens
RP-73401 IC50: 0.0089 mM, PDE5 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
T-84 cell PDE5 Homo sapiens
-

Synonyms

Synonyms Comment Organism
PDE4
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000021
-
 IC50: 0.000021 mM, PDE5 Homo sapiens quinazolinamine
0.00067
-
 IC50: 0.00067 mM, PDE5 Homo sapiens (2Z)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one
0.002
-
 IC50: 0.002 mM, PDE5 Homo sapiens 2-[1-(2,4-dichlorobenzyl)-2-methyl-5-(methylmercapto)-1H-indol-3-yl] ethanaminium chloride
0.006
-
 IC50: 0.006 mM, PDE5 Homo sapiens Cilostamide
0.0089
-
 IC50: 0.0089 mM, PDE5 Homo sapiens RP-73401