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Literature summary for 3.1.4.35 extracted from
- Reciprocal regulation of cyclic GMP content by cyclic GMP-phosphodiesterase and guanylate cyclase in SHR with CsA-induced nephrotoxicity (2001), Br. J. Pharmacol., 134, 995-1002.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanosine 3',5'-cyclic phosphate + H2O | Rattus norvegicus | - |
guanosine 5'-phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
spontaneous hypertensive rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | 28fold decrease in cGMP-phosphodiesterase after treatment of animals with 50 mg/kg cyclosporin A | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| guanosine 3',5'-cyclic phosphate + H2O | - |
Rattus norvegicus | guanosine 5'-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cyclic GMP-phosphodiesterase | - |
Rattus norvegicus |
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