Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sildenafil | 0.0000035 mM, 50% inhibition | Mus musculus | |
zaprinast | 0.0006 mM, 50% inhibition | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
98000 | - |
x * 98000, immunoblot | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanosine 3',5'-cyclic phosphate + H2O | Mus musculus | - |
guanosine 5'-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Mono Q, gel filtration, partially purified from N18TG2 and NG108-15 neuroblastoma cells | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | low expression | Mus musculus | - |
cerebellum | - |
Mus musculus | - |
heart | - |
Mus musculus | - |
kidney | low expression | Mus musculus | - |
liver | very low expression | Mus musculus | - |
lung | highest PDE5 expression | Mus musculus | - |
neuroblastoma cell | PDE5 is induced in neuroblastoma-glioma NG108-15 cells after dibutyryl treatment | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00061 | - |
partially purified PDE5 from N18TG2 neuroblastoma cells | Mus musculus |
1.44 | - |
partially purified PDE5 from NG108-15 neuroblastoma cells | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanosine 3',5'-cyclic phosphate + H2O | - |
Mus musculus | guanosine 5'-phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 98000, immunoblot | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
cGMP-binding cGMP-specific phosphodiesterase | - |
Mus musculus |
PDE5 | - |
Mus musculus |