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Literature summary for 3.1.4.35 extracted from

  • Sudo, T.; Tachibana, K.; Toga, K.; Tochizawa, S.; Inoue, Y.; Kimura, Y.; Hidaka, H.
    Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity (2000), Biochem. Pharmacol., 59, 347-356.
    View publication on PubMed
Search for more literature for 3.1.4.35

Cloned(Commentary)

Cloned (Comment) Organism
baculovirus-expressed PDE5 in Sf9 cells Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
(-)-6-(3-(3-cyclopropyl-3-((1R,2R)-2-hydroxycyclohexyl)ureido)-propoxy)-2(1H)-quinolinone IC50: 0.0121 mM, PDE5 Bos taurus
2-cyclohexyl-2-methyl-N1-[3-(2-oxo-1,2-dihydro-6-quinolyl,oxy)propyl]-1-hydrazinecarboxamide IC50: 0.0027 mM, PDE5 Bos taurus
6-(3-(3-cyclooctyl-3-((1R,2R)-2-hydroxycyclohexyl)ureido)-propoxy)-2(1H)-quinolinone IC50: 0.0025 mM, PDE5 Bos taurus
amrinone IC50: 0.2296 mM, PDE5 Bos taurus
Cilostamide IC50: 0.0152 mM, PDE5 Bos taurus
cilostazol IC50: 0.0044 mM, PDE5 Bos taurus
dipyridamole IC50: 0.00026 mM, PDE5 Bos taurus
Milrinone IC50: 0.0491 mM, PDE5 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00098
-
 3',5'-cAMP 30°C, pH 8.0, PDE5 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
 Bos taurus 5'-AMP
-
 ?
3',5'-cGMP + H2O PDE5 Bos taurus guanosine 5'-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PDE5
-
 Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00026
-
 IC50: 0.00026 mM, PDE5 Bos taurus dipyridamole
0.0025
-
 IC50: 0.0025 mM, PDE5 Bos taurus 6-(3-(3-cyclooctyl-3-((1R,2R)-2-hydroxycyclohexyl)ureido)-propoxy)-2(1H)-quinolinone
0.0027
-
 IC50: 0.0027 mM, PDE5 Bos taurus 2-cyclohexyl-2-methyl-N1-[3-(2-oxo-1,2-dihydro-6-quinolyl,oxy)propyl]-1-hydrazinecarboxamide
0.0044
-
 IC50: 0.0044 mM, PDE5 Bos taurus cilostazol
0.0121
-
 IC50: 0.0121 mM, PDE5 Bos taurus (-)-6-(3-(3-cyclopropyl-3-((1R,2R)-2-hydroxycyclohexyl)ureido)-propoxy)-2(1H)-quinolinone
0.0152
-
 IC50: 0.0152 mM, PDE5 Bos taurus Cilostamide
0.0491
-
 IC50: 0.0491 mM, PDE5 Bos taurus Milrinone
0.2296
-
 IC50: 0.2296 mM, PDE5 Bos taurus amrinone