Inhibitors | Comment | Organism | Structure |
---|---|---|---|
tricyclodecan-9-yl-xanthogenate | i.e. D609, a specific inhibitor, prevents the development of acute hypoxic pulmonary hypertension in rats, and also inhibits pulmonary vasoconstriction induced with a generator of superoxide anions LY83583, but not the one induced with hydrogen peroxide | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + H2O | Rattus norvegicus | - |
1,2-sn-diacylglycerol + phosphocholine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
artery | intrapulmonary arteries | Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylcholine + H2O | - |
Rattus norvegicus | 1,2-sn-diacylglycerol + phosphocholine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PC-PLC | - |
Rattus norvegicus |
phosphatidylcholine-specific phospholipase C | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme plays an important role in sustained hypoxic pulmonary vasoconstriction possibly through the activation of protein kinase C-independent mechanism, which may be coupled with phosphocholine release. Phosphocholine induces sustained contraction in isolated intrapulmonary arteries and also transient pulmonary and systemic hypertension if administered intravenously | Rattus norvegicus |