Inhibitors | Comment | Organism | Structure |
---|---|---|---|
tricyclodecan-9-ylxanthogenate | i.e. D609, a rather selective PC-PLC inhibitor | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | interaction between PC-PLC and cell division cycle 20 homologue, Cdc20, initiating the degradation of PC-PLC by Cdc20-mediated ubiquitin proteasome pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CBRH-7919 cell | a rat hepatoma cell line established from N-nitrosodiethyla-mine-induced Wistar rat hepatoma | Rattus norvegicus | - |
liver cell line | rat liver cell line | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | interaction between PC-PLC and cell division cycle 20 homologue, Cdc20, initiating the degradation of PC-PLC by Cdc20-mediated ubiquitin proteasome pathway | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PC-PLC | - |
Rattus norvegicus |
phosphatidylcholine-specific phospholipase C | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | phosphatidylcholine-specific phospholipase C is the major enzyme in the phosphatidylcholine cycle and is involved in many long-term cellular responses such as activation, proliferation, and differentiation events. Functional roles of PC-PLC and Cdc20 in the cell cycle, mitosis, and apoptosis in CBRH-7919 cancer cells. PC-PLC is involved in cell proliferation | Rattus norvegicus |