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Literature summary for 3.1.4.3 extracted from

  • Chen, Z.; Yu, Y.; Fu, D.; Li, Z.; Niu, X.; Liao, M.; Lu, S.
    Functional roles of PC-PLC and Cdc20 in the cell cycle, proliferation, and apoptosis (2010), Cell Biochem. Funct., 28, 249-257.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
tricyclodecan-9-ylxanthogenate i.e. D609, a rather selective PC-PLC inhibitor Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus interaction between PC-PLC and cell division cycle 20 homologue, Cdc20, initiating the degradation of PC-PLC by Cdc20-mediated ubiquitin proteasome pathway ?
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
CBRH-7919 cell a rat hepatoma cell line established from N-nitrosodiethyla-mine-induced Wistar rat hepatoma Rattus norvegicus
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liver cell line rat liver cell line Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information interaction between PC-PLC and cell division cycle 20 homologue, Cdc20, initiating the degradation of PC-PLC by Cdc20-mediated ubiquitin proteasome pathway Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
PC-PLC
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Rattus norvegicus
phosphatidylcholine-specific phospholipase C
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Rattus norvegicus

General Information

General Information Comment Organism
physiological function phosphatidylcholine-specific phospholipase C is the major enzyme in the phosphatidylcholine cycle and is involved in many long-term cellular responses such as activation, proliferation, and differentiation events. Functional roles of PC-PLC and Cdc20 in the cell cycle, mitosis, and apoptosis in CBRH-7919 cancer cells. PC-PLC is involved in cell proliferation Rattus norvegicus