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Literature summary for 3.1.4.3 extracted from

  • Montes, L.-R.; Lopez, D.J.; Sot, J.; Bagatolli, L.A.; Stonehouse, M.J.; Vasil, M.L.; Wu, B.X.; Hannun, Y.A.; Goni, F.M.; Alonso, A.
    Ceramide-enriched membrane domains in red blood cells and the mechanism of sphingomyelinase-induced hot-cold hemolysis (2008), Biochemistry, 47, 11222-11230.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Pseudomonas aeruginosa The sphingomyelinase, but not the phospholipase C activity, is essential for induction of hot-cold hemolysis in human erythrocytes, that contain both phosphatidylcholine and sphingomyelin but also in goat erythrocytes, which lack phosphatidylcholine, however, in horse erythrocytes, with a large proportion of phosphatidylcholine and almost no sphingomyelin, hot-cold hemolysis induced by PlcHR2 is not observed, overview ?
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Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information The sphingomyelinase, but not the phospholipase C activity, is essential for induction of hot-cold hemolysis in human erythrocytes, that contain both phosphatidylcholine and sphingomyelin but also in goat erythrocytes, which lack phosphatidylcholine, however, in horse erythrocytes, with a large proportion of phosphatidylcholine and almost no sphingomyelin, hot-cold hemolysis induced by PlcHR2 is not observed, overview Pseudomonas aeruginosa ?
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additional information PlcHR2 toxin from Pseudomonas aeruginosa is an enzyme with both phospholipase C and sphingomyelinase activities, PlcHR2 hydrolyzes phosphatidylcholine and sphingomyelin at similar rates, but other phospholipids are cleaved at much lower rates, if at all Pseudomonas aeruginosa ?
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Synonyms

Synonyms Comment Organism
More cf. EC 3.1.4.12, the enzyme is the prototype of another phosphatase superfamily Pseudomonas aeruginosa
phospholipase C/sphingomyelinase
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Pseudomonas aeruginosa
PlcHR2
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Pseudomonas aeruginosa
PlcHR2 toxin
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Pseudomonas aeruginosa