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Literature summary for 3.1.4.3 extracted from

  • Cecchetti, S.; Spadaro, F.; Lugini, L.; Podo, F.; Ramoni, C.
    Functional role of phosphatidylcholine-specific phospholipase C in regulating CD16 membrane expression in natural killer cells (2007), Eur. J. Immunol., 37, 2912-2922.
    View publication on PubMed
Search for more literature for 3.1.4.3

Inhibitors

Inhibitors Comment Organism Structure
D609 inhibitor of isoform PC-PLC, preincubation with D609 results in a dramatic decrease both in CD16 receptor and PC-PLC expression on the plasma membrane and reduction of CD16-mediated cytotoxicity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane association of isoform PC-PLC with CD16 receptor, partial accumulation of both in lipid rafts. Antibody-mediated CD16 cross-linking results in an about twofold increase in PC-PLC enzyme activity within 10 min Homo sapiens 5886
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens isoform PC-PLC plays an important role in regulating CD16 receptor membrane expression, the CD16-mediated cytolytic mechanism and CD16-triggered signal transduction ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
natural killer cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoform PC-PLC plays an important role in regulating CD16 receptor membrane expression, the CD16-mediated cytolytic mechanism and CD16-triggered signal transduction Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More physical association of isoform PC-PLC with CD16 receptor, partial accumulation of both in lipid rafts Homo sapiens