Literature summary for 3.1.4.3 extracted from

Fantuzzi, L.; Spadaro, F.; Purificato, C.; Cecchetti, S.; Podo, F.; Belardelli, F.; Gessani, S.; Ramoni, C.
Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages (2008), Blood, 111, 3355-3363.

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Application

Application	Comment	Organism
medicine	chemokine CCL2, i.e. MCP-1, enhances HIV-1 replication. Enzyme isoform PC-PLC is activated by HIV-1 R5 gp120 interaction with CCR5 and is required for NF-kB-mediated CCL2 production triggered by R5 gp120 in monocyte-derived macrophages	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform PC-PLC	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	monocyte-derived macrophage, enzyme is activated by HIV-1 R5 gp120 interaction with CCR5 and is required for NF-kB-mediated chemokine CCL2 production triggered by R5 gp120	Homo sapiens	-

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Release 2023.1 (January 2023)