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Literature summary for 3.1.4.3 extracted from

  • Liu, H.; Zhang, H.; Forman, H.J.
    Silica induces macrophage cytokines through phosphatidylcholine-specific phospholipase C with hydrogen peroxide (2007), Am. J. Respir. Cell Mol. Biol., 36, 594-599.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.3

Activating Compound

Activating Compound Comment Organism Structure
H2O2 exogenous H2O2 increases enzyme activity Rattus norvegicus
silica particle enzyme activity in macrophage increases significantly upon exposure to silica particles. Increase in activity is inhibited by Mn(III)tetrakis(4-benzoic acid)porphyrin chloride Rattus norvegicus

Application

Application Comment Organism
medicine isoform PC-PLC plays a critical role in the silica-associated inflammatory response of alveolar macrophage Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
D609 inhibition of isoform PC-PLC blocks the silica-stimulated induction of TNF-alpha and interleukin-1beta Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus enzyme is regulated through redox- and calcium-dependent manners in alveolar macrophage ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
macrophage alveolar macrophage Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is regulated through redox- and calcium-dependent manners in alveolar macrophage Rattus norvegicus ?
-
 ?