Literature summary for 3.1.4.3 extracted from

Strosznajder, R.P.; Pokorski, M.
Regulation of phospholipase C activity by calcium ions and guanine nucleotide in the normoxic cat carotid body (2000), Neurochem. Res., 25, 739-743.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Ca2+	required, isoform acting on inositol-phosphatidylinositol	Felis catus
GTPgammaS	isoform acting on inositol-phosphatidylinositol-4,5-bisphosphate	Felis catus

Inhibitors

Inhibitors	Comment	Organism	Structure
EDTA	isoform acting on inositol-phosphatidylinositol	Felis catus

Organism

Organism	UniProt	Comment	Textmining
Felis catus	-	two isozymes	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
carotid body	-	Felis catus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphatidylinositol + H2O	Ca2+-dependent activity	Felis catus	inositol monophosphate + diacylglycerol	-	?
phosphatidylinositol 4,5-bisphosphate + H2O	Ca2+-independent activity	Felis catus	inositol 4,5-bisphosphate + phosphatidate	-	?

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Release 2023.1 (January 2023)