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Literature summary for 3.1.4.2 extracted from
- Accumulation of glycerophosphocholine (GPC) by renal cells: Osmotic regulation of GPC:choline phosphodiesterase (1991), Proc. Natl. Acad. Sci. USA, 88, 7820-7824.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NaCl | cells grown in hyperosmotic medium, 66% inhibition within 6-48 h | Canis lupus |  |
| NaCl | cells grown in hyperosmotic medium, 66% inhibition within 6-48 h | Oryctolagus cuniculus | |
| Urea | - |
Canis lupus | |
| Urea | - |
Oryctolagus cuniculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sn-glycero 3-phosphorylcholine + H2O | Oryctolagus cuniculus | cellular phosphatidylcholine catabolic pathway | ? | - |
? | |
| sn-glycero 3-phosphorylcholine + H2O | Canis lupus | cellular phosphatidylcholine catabolic pathway | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus | - |
- |
- |
| Oryctolagus cuniculus | - |
rabbit | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epithelium | - |
Oryctolagus cuniculus | - |
| epithelium | - |
Canis lupus | - |
| MDCK cell | - |
Canis lupus | - |
| PAP-HT25 cell | PAP-HT25 renal medullary epithelial cells | Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sn-glycero 3-phosphorylcholine + H2O | - |
Oryctolagus cuniculus | sn-glycerol 3-phosphate + choline | - |
? | |
| sn-glycero 3-phosphorylcholine + H2O | - |
Canis lupus | sn-glycerol 3-phosphate + choline | - |
? | |
| sn-glycero 3-phosphorylcholine + H2O | cellular phosphatidylcholine catabolic pathway | Oryctolagus cuniculus | ? | - |
? | |
| sn-glycero 3-phosphorylcholine + H2O | cellular phosphatidylcholine catabolic pathway | Canis lupus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GPC:choline phosphodiesterase | - |
Oryctolagus cuniculus |
| GPC:choline phosphodiesterase | - |
Canis lupus |
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