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Literature summary for 3.1.4.17 extracted from
- Revisiting bacterial cyclic nucleotide phosphodiesterases cyclic AMP hydrolysis and beyond (2015), FEMS Microbiol. Lett., 362, fnv183 .
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.003 | - |
3',5'-cAMP | isoform PdeA, pH and temperature not specified in the publication | Myxococcus xanthus |  |
| 0.005 | - |
3',5'-cAMP | isoform PdeB, pH and temperature not specified in the publication | Myxococcus xanthus | |
| 0.007 | - |
3',5'-cAMP | pH and temperature not specified in the publication | Pseudomonas aeruginosa | |
| 0.045 | - |
3',5'-cAMP | pH and temperature not specified in the publication | Anabaena sp. | |
| 0.35 | - |
3',5'-cAMP | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | activates | Mycobacterium tuberculosis | |
| Co2+ | activates isoform PdeB | Myxococcus xanthus | |
| Fe2+ | required | Pseudomonas aeruginosa | |
| Fe2+ | activates | Anabaena sp. | |
| Fe3+ | required | Pseudomonas aeruginosa | |
| Fe3+ | activates | Mycobacterium tuberculosis | |
| Mg2+ | activates | Mycobacterium tuberculosis | |
| Mn2+ | activates | Anabaena sp. | |
| Mn2+ | activates | Mycobacterium tuberculosis | |
| Mn2+ | activates isoforms PdeA and PdeB | Myxococcus xanthus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Anabaena sp. | - |
- |
- |
| Mycobacterium tuberculosis | P9WP65 | - |
- |
| Myxococcus xanthus | - |
- |
- |
| Pseudomonas aeruginosa | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2',3'-cAMP + H2O | - |
Myxococcus xanthus | ? | - |
? | |
| 2',3'-cAMP + H2O | - |
Mycobacterium tuberculosis | ? | - |
? | |
| 3',5'-cAMP + H2O | - |
Pseudomonas aeruginosa | 5'-AMP | - |
? | |
| 3',5'-cAMP + H2O | - |
Myxococcus xanthus | 5'-AMP | - |
? | |
| 3',5'-cAMP + H2O | - |
Anabaena sp. | 5'-AMP | - |
? | |
| 3',5'-cAMP + H2O | - |
Mycobacterium tuberculosis | 5'-AMP | - |
? | |
| 3',5'-cGMP + H2O | - |
Pseudomonas aeruginosa | 5'-GMP | - |
? | |
| 3',5'-cGMP + H2O | - |
Anabaena sp. | 5'-GMP | - |
? | |
| 3',5'-cGMP + H2O | - |
Mycobacterium tuberculosis | 5'-GMP | - |
? | |
| 5'-AMP + H2O | - |
Myxococcus xanthus | ? | - |
? | |
| 5'-ATP + H2O | - |
Myxococcus xanthus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CpdA | - |
Pseudomonas aeruginosa |
| CpdA | - |
Anabaena sp. |
| cyclic nucleotide phosphodiesterase | - |
Pseudomonas aeruginosa |
| cyclic nucleotide phosphodiesterase | - |
Myxococcus xanthus |
| cyclic nucleotide phosphodiesterase | - |
Anabaena sp. |
| cyclic nucleotide phosphodiesterase | - |
Mycobacterium tuberculosis |
| PDE | - |
Pseudomonas aeruginosa |
| PDE | - |
Myxococcus xanthus |
| PDE | - |
Anabaena sp. |
| PDE | - |
Mycobacterium tuberculosis |
| PdeA | isoform | Myxococcus xanthus |
| PdeB | isoform | Myxococcus xanthus |
| Rv0805 | - |
Mycobacterium tuberculosis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | isoforms PdeA and PdeB participate in osmotic adaptation and temperature adaptation | Myxococcus xanthus |
| physiological function | the enzyme participates in cell wall permeability and virulence | Anabaena sp. |
| physiological function | the enzyme participates in cell wall permeability and virulence | Mycobacterium tuberculosis |
| physiological function | the enzyme participates in twitching motility and virulence factor expression | Pseudomonas aeruginosa |
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