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Literature summary for 3.1.4.17 extracted from

  • Zhang, F.; Qi, Y.; Zhou, K.; Zhang, G.; Linask, K.; Xu, H.
    The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM (2015), EMBO Rep., 16, 520-527 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.17

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Rosetta 2(DE3) cells Drosophila melanogaster

Inhibitors

Inhibitors Comment Organism Structure
3-isobutyl-1-methylxanthine
-
 Drosophila melanogaster

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01797
-
 3',5'-cGMP pH and temperature not specified in the publication Drosophila melanogaster
0.01942
-
 3',5'-cAMP pH and temperature not specified in the publication Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial matrix
-
 Drosophila melanogaster 5759
-

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Drosophila melanogaster

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
 Drosophila melanogaster 5'-AMP
-
 ?
3',5'-cGMP + H2O
-
 Drosophila melanogaster 5'-GMP
-
 ?

Synonyms

Synonyms Comment Organism
Prune
-
 Drosophila melanogaster

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.00123
-
 3',5'-cGMP pH and temperature not specified in the publication Drosophila melanogaster
0.00206
-
 3',5'-cAMP pH and temperature not specified in the publication Drosophila melanogaster

General Information

General Information Comment Organism
physiological function the enzyme stabilizes mitochondrial transcription factor A and promotes mitochondrial DNA replication through downregulation of mitochondrial cAMP signaling Drosophila melanogaster