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Literature summary for 3.1.4.17 extracted from

  • Adderley, S.P.; Sprague, R.S.; Stephenson, A.H.; Hanson, M.S.
    Regulation of cAMP by phosphodiesterases in erythrocytes (2010), Pharmacol. Rep., 62, 475-482.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
cGMP binding of cGMP to GAF domains within PDE2 results in the activation of all PDE2 variants Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cGMP the hydrolysis of cGMP by PDE3 inhibits the hydrolysis of cAMP Homo sapiens
EHNA a selective PDE2 inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane PDE2A2 and PDE2A3, and PDE3A and PDE3B Homo sapiens 16020
-
soluble PDE2A1 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein in adipocytes, insulin induces formation of macromolecular complexes containing signaling molecules such as IRS-1, PI3K and PKB, proteins involved in PDE3B activation/phosphorylation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
Homo sapiens
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cardiac myocyte
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Homo sapiens
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erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine 3',5'-cyclic phosphate + H2O
-
Homo sapiens adenosine 5'-phosphate
-
?
guanosine 3',5'-cyclic phosphate + H2O
-
Homo sapiens guanosine 5'-phosphate
-
?
additional information PDE2 can hydrolyze both cAMP and cGMP with similar maximal rates. PDE1A prefers cGMP, PDE1B cAMP, and PDE1C hydrolyzes both substrates equally. The PDE3 family can hydrolyze both cAMP and cGMP Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
cGMP-inhibited PDE
-
Homo sapiens
PDE1
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Homo sapiens
PDE1A
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Homo sapiens
PDE1B
-
Homo sapiens
PDE1C
-
Homo sapiens
PDE2
-
Homo sapiens
PDE2A1
-
Homo sapiens
PDE2A2
-
Homo sapiens
PDE2A3
-
Homo sapiens
PDE3A
-
Homo sapiens
PDE3B
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens epinephrine infusion stimulates skeletal muscle PDE2A expression up

General Information

General Information Comment Organism
metabolism in adipocytes, insulin induces formation of macromolecular complexes containing signaling molecules such as IRS-1, PI3K and PKB, proteins involved in PDE3B activation/phosphorylation Homo sapiens
physiological function in erythrocytes, PDE3 selectively regulates cAMP synthesis stimulates by activation of the IP receptor. The isoform of PDE1 present in these erythrocytes is primarily involved in hydrolysis of cGMP. The regulated release of ATP from erythrocytes occurs via a defined signaling pathway and requires increases in cAMP. It is well recognized that cAMP is a critical second messenger in diverse signaling pathways. In all cells increases in cAMP are localized and regulated by the activity of phosphodiesterases, PDEs. The subcellular localization of PDEs is recognized to be a key mechanism for compartmentalization of cyclic nucleotide signaling. PDEs within these cells regulate the compartmentalization of cAMP signaling allowing for specific cell responses. The subcellular location of PDEs is critical for coupling these enzymes to specific signal transduction pathways, which permit specific PDEs to regulate local increases in cAMP produced by activation of ligand specific receptor Homo sapiens