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Literature summary for 3.1.4.17 extracted from

  • Penmatsa, H.; Zhang, W.; Yarlagadda, S.; Li, C.; Conoley, V.G.; Yue, J.; Bahouth, S.W.; Buddington, R.K.; Zhang, G.; Nelson, D.J.; Sonecha, M.D.; Manganiello, V.; Wine, J.J.; Naren, A.P.
    Compartmentalized cyclic adenosine 3',5'-monophosphate at the plasma membrane clusters PDE3A and cystic fibrosis transmembrane conductance regulator into microdomains (2010), Mol. Biol. Cell, 21, 1097-1110.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.17

Cloned(Commentary)

Cloned (Comment) Organism
PDE3A expression in HEK-293 cells on the plasma membrane Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
adenosine
-
 Homo sapiens
adenosine
-
 Sus scrofa
cilostazol a PDE3 inhibitor Homo sapiens
cilostazol a PDE3 inhibitor Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-
plasma membrane
-
 Sus scrofa 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PDE3A physically and functionally interacts with cystic fibrosis transmembrane conductance regulator, CFTR, channel ?
-
 ?
additional information Sus scrofa PDE3A physically and functionally interacts with cystic fibrosis transmembrane conductance regulator, CFTR, channel ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Calu-3 cell
-
 Homo sapiens
-
epithelial cell
-
 Homo sapiens
-
epithelial cell
-
 Sus scrofa
-
lung trachea submucosal gland Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PDE3A physically and functionally interacts with cystic fibrosis transmembrane conductance regulator, CFTR, channel Homo sapiens ?
-
 ?
additional information PDE3A physically and functionally interacts with cystic fibrosis transmembrane conductance regulator, CFTR, channel Sus scrofa ?
-
 ?

Synonyms

Synonyms Comment Organism
PDE3A
-
 Homo sapiens
PDE3A
-
 Sus scrofa
phosphodiesterase type 3A
-
 Homo sapiens
phosphodiesterase type 3A
-
 Sus scrofa

General Information

General Information Comment Organism
physiological function PDE3A physically and functionally interacts with cystic fibrosis transmembrane conductance regulator, CFTR, channel. PDE3A inhibition generates compartmentalized cAMP, which further clusters PDE3A and CFTR into microdomains at the plasma membrane and potentiates CFTR channel function. Actin skeleton disruption reduces PDE3A-CFTR interaction and segregates PDE3A from its interacting partners, thus compromising the integrity of the CFTR-PDE3A-containing macromolecular complex, compartmentalized cAMP signaling is lost Homo sapiens
physiological function PDE3A physically and functionally interacts with cystic fibrosis transmembrane conductance regulator, CFTR, channel. PDE3A inhibition generates compartmentalized cAMP, which further clusters PDE3A and CFTR into microdomains at the plasma membrane and potentiates CFTR channel function. Actin skeleton disruption reduces PDE3A-CFTR interaction and segregates PDE3A from its interacting partners, thus compromising the integrity of the CFTR-PDE3A-containing macromolecular complex, compartmentalized cAMP signaling is lost Sus scrofa