Literature summary for 3.1.4.17 extracted from

Lu, H.; Goren, A.C.; Zhan, C.G.
Characterization of the structures of phosphodiesterase 10 binding with adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate by hybrid quantum mechanical/molecular mechanical calculations (2010), J. Phys. Chem. B, 114, 7022-7028.

Search for more literature for 3.1.4.17

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	is coordinated to Asp564, two phosphate oxygen atoms, and three water molecules	Homo sapiens
Zn2+	is coordinated to His529, His563, Asp564, Asp674, and two phosphate oxygen atoms	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	structure analysis of phosphodiesterase 10 binding with cAMP and cGMP by hybrid quantum mechanical/molecular mechanical calculations using cyrstal structures of the substrate-bound enzyme, detailed overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
adenosine 3',5'-cyclic phosphate + H2O	-	Homo sapiens	adenosine 5'-phosphate	-	?
guanosine 3',5'-cyclic phosphate + H2O	-	Homo sapiens	guanosine 5'-phosphate	-	?
additional information	structure analysis of phosphodiesterase 10 binding with cAMP and cGMP by hybrid quantum mechanical/molecular mechanical calculations using cyrstal structures of the substrate-bound enzyme, detailed overview	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
PDE10	-	Homo sapiens
phosphodiesterase 10	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)