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Literature summary for 3.1.4.17 extracted from

  • Bender, A.T.; Beavo, J.A.
    PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte (2006), Proc. Natl. Acad. Sci. USA, 103, 460-465.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information inhibition of isoform PDE1B2 induction by RNAi results. Expression of PDE1B2 short hairpin RNA effectivly suppresses enzyme mRNA, protein, and activity-upregulation upon treatment with phorbol-12-myristate-13-acetate and results in augmented cell spreading, phagocyte ability, and CD11b expression. Enzyme knock-down cells have lower basal levels of cAMP and alterations in the phosphorylation state of several probabl protein kinase A substrate proteins Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ isoform PDE1B2 activity can be regulated by changes in Ca2+ levels Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens isoform PDE1B2 predominantly regulates cGMP and plays a lesser role in cAMP regulation in response to cyclase agonists ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isoform PDE1B2
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoform PDE1B2 predominantly regulates cGMP and plays a lesser role in cAMP regulation in response to cyclase agonists Homo sapiens ?
-
 ?