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Literature summary for 3.1.4.17 extracted from

  • de Vente, J.; Markerink-van Ittersum, M.; Vles, J.S.
    The role of phosphodiesterase isoforms 2, 5, and 9 in the regulation of NO-dependent and NO-independent cGMP production in the rat cervical spinal cord (2006), J. Chem. Neuroanat., 31, 275-303.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus cGMP levels in the spinal cord are controlled by a number of enzyme isoforms, that can be present in the same cell. Role of NO-cGMP signaling in nociceptive processing ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q01062
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Source Tissue

Source Tissue Comment Organism Textmining
spinal cord cervical spinal cord, expression of isoforms PDE2, PDE5, and PDE9 in all lamina, in ventral motor neurons and in ependymal cells lining the central canal. Study on the influence of enzyme activity on NO-stimulated cGMP levels Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cGMP levels in the spinal cord are controlled by a number of enzyme isoforms, that can be present in the same cell. Role of NO-cGMP signaling in nociceptive processing Rattus norvegicus ?
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?