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Literature summary for 3.1.4.17 extracted from

  • Surapisitchat, J.; Jeon, K.I.; Yan, C.; Beavo, J.A.
    Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3 (2007), Circ. Res., 101, 811-818.
    View publication on PubMed
Search for more literature for 3.1.4.17

Activating Compound

Activating Compound Comment Organism Structure
cGMP about 30fold stimulation of isoform PDE2A with EC50 value of 0.0011 mM Homo sapiens

Application

Application Comment Organism
medicine the effect of increasing concentrations of cGMP on endothelial permeability is biphasic, attributable to the relative amounts of enzyme isoforms PDE2A and PDE3A in endothelial cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
cGMP
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the effect of increasing concentrations of cGMP on endothelial permeability is biphasic, attributable to the relative amounts of enzyme isoforms PDE2A and PDE3A in endothelial cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isoforms PDE2A, PDE3A
-

Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the effect of increasing concentrations of cGMP on endothelial permeability is biphasic, attributable to the relative amounts of enzyme isoforms PDE2A and PDE3A in endothelial cells Homo sapiens ?
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000059
-
 isoform PDE3A Homo sapiens cGMP