Literature summary for 3.1.4.17 extracted from

Witwicka, H.; Kobialka, M.; Siednienko, J.; Mitkiewicz, M.; Gorczyca, W.A.
Expression and activity of cGMP-dependent phosphodiesterases is up-regulated by lipopolysaccharide (LPS) in rat peritoneal macrophages (2007), Biochim. Biophys. Acta, 1773, 209-218.

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Activating Compound

Activating Compound	Comment	Organism	Structure
lipopolysaccharide	expression and activity of isoforms PDE2, PDE3, PDE11 in cultured peritoneal macrophages are recovered after treatment of cultured cells with lipopolysaccharide. Lipopolysaccharide also up-regulates enzyme expression in resident peritoneal macrophages	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	isoforms PDE1, PDE2,PDE3, PDE10, PDE11	Rattus norvegicus	5737	-
membrane	isoforms PDE2,PDE3, PDE10, PDE11	Rattus norvegicus	16020	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	isoforms PDE1, PDE2, PDE3, PDE10, PDe11	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
peritoneal macrophage	in freshly isolated peritoneal exudate macrophage, isoforms PDE1, PDE2, PDE3, PDE10, PDE11 are expressed. After 24h of cultures, levels of isoforms PDE2, PDE3, and PDE11 are markedly decreased. Their expression and activity are recovered after treatment of cultured cells with lipopolysaccharide	Rattus norvegicus	-

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Release 2023.1 (January 2023)