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Literature summary for 3.1.4.17 extracted from
- Isoforms of cyclic nucleotide phosphodiesterase PDE3 and their contribution to cAMP hydrolytic activity in subcellular fractions of human myocardium (2005), J. Biol. Chem., 280, 39168-39174.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3',5'-cGMP | - |
Homo sapiens |  |
| cilostazol | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000079 | - |
3',5'-cAMP | isoform PDE3A-94 | Homo sapiens | |
| 0.000088 | - |
3',5'-cAMP | isoform PDE3A-136 | Homo sapiens | |
| 0.000093 | - |
3',5'-cAMP | isoform PDE3A-118 | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3',5'-cAMP + H2O | Homo sapiens | inhibition of cAMP hydrolysis by cGMP is likely to contribute to cGMP-mediated signaling in myocardium | 5'-AMP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| myocardium | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3',5'-cAMP + H2O | - |
Homo sapiens | 5'-AMP | - |
? | |
| 3',5'-cAMP + H2O | inhibition of cAMP hydrolysis by cGMP is likely to contribute to cGMP-mediated signaling in myocardium | Homo sapiens | 5'-AMP | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cyclic nucleotide phosphodiesterase PDE3 | - |
Homo sapiens |
| PDE3 | - |
Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.48 | - |
3',5'-cAMP | isoform PDE3A-136 | Homo sapiens | |
| 0.5 | - |
3',5'-cAMP | isoform PDE3A-118 | Homo sapiens | |
| 0.52 | - |
3',5'-cAMP | isoform PDE3A-94 | Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00002 | - |
3',5'-cGMP | isoform PDE3A-118 | Homo sapiens | |
| 0.000028 | - |
3',5'-cGMP | isoform PDE3A-94 | Homo sapiens | |
| 0.00003 | - |
3',5'-cGMP | isoform PDE3A-136 | Homo sapiens | |
| 0.000039 | - |
cilostazol | isoform PDE3A-118 | Homo sapiens | |
| 0.00005 | - |
cilostazol | isoform PDE3A-136 | Homo sapiens | |
| 0.000056 | - |
cilostazol | isoform PDE3A-94 | Homo sapiens | |
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