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Literature summary for 3.1.4.17 extracted from
- A FYVE-containing unusual cyclic nucleotide phosphodiesterase from Trypanosoma cruzi (2005), FEBS J., 272, 6412-6422.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Saccharomyces cerevisiae | Trypanosoma cruzi |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione | IC50: 0.068 mM | Trypanosoma cruzi |  |
| dipyridamole | IC50: 0.0069 mM | Trypanosoma cruzi | |
| etazolate | IC50: 0.0007 mM | Trypanosoma cruzi | |
| papaverine | IC50: 0.025 mM | Trypanosoma cruzi | |
| trequinsin | IC50: 0.0039 mM | Trypanosoma cruzi | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0316 | - |
3',5'-cAMP | - |
Trypanosoma cruzi | |
| 0.0782 | - |
3',5'-cGMP | - |
Trypanosoma cruzi | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| kinetoplast | - |
Trypanosoma cruzi | 20023 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| CaCl2 | entirely dependent on the presence of divalent cations, activity with 0.2 mM CaCl2 is 15.9% of maximal activity obtained with 2 mM MgCl2 | Trypanosoma cruzi | |
| Mg2+ | entirely dependent on the presence of divalent cations, maximal activity with 2 mM MgCl2 | Trypanosoma cruzi | |
| Mn2+ | entirely dependent on the presence of divalent cations, activity with 2 mM MnCl2 is 53.5% of maximal activity obtained with 2 mM MgCl2 | Trypanosoma cruzi | |
| Zn2+ | entirely dependent on the presence of divalent cations, activity with 0.03 mM ZnCl2 is 19.5% of maximal activity obtained with 2 mM MgCl2 | Trypanosoma cruzi | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 103169 | - |
x * 103169, calculated from sequence | Trypanosoma cruzi |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma cruzi | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3',5'-cAMP + H2O | - |
Trypanosoma cruzi | 5'-AMP | - |
? | |
| 3',5'-cGMP + H2O | - |
Trypanosoma cruzi | 5'-GMP | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 103169, calculated from sequence | Trypanosoma cruzi |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dual-specificity PDE | - |
Trypanosoma cruzi |
| TcrPDEC | - |
Trypanosoma cruzi |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Trypanosoma cruzi | calculated from sequence | - |
5.9 |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0007 | - |
IC50: 0.0007 mM | Trypanosoma cruzi | etazolate | |
| 0.0039 | - |
IC50: 0.0039 mM | Trypanosoma cruzi | trequinsin | |
| 0.0069 | - |
IC50: 0.0069 mM | Trypanosoma cruzi | dipyridamole | |
| 0.025 | - |
IC50: 0.025 mM | Trypanosoma cruzi | papaverine | |
| 0.068 | - |
IC50: 0.068 mM | Trypanosoma cruzi | 3-isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione | |
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Release 2023.1 (January 2023)
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