Literature summary for 3.1.4.17 extracted from

D'Angelo, A.; Garzia, L.; Andre, A.; Carotenuto, P.; Aglio, V.; Guardiola, O.; Arrigoni, G.; Cossu, A.; Palmieri, G.; Aravind, L.; Zollo, M.
Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis (2004), Cancer Cell, 5, 137-149.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression by using a baculovirus expression system	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
D106A	mutation does not influence h-prune phosphodiesterase activity	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
3-isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione	IC50: 0.0402 mM	Homo sapiens
dipyridamole	IC50: 0.00078 mM	Homo sapiens
vinpocetine	IC50: 0.0223	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0009	-	3',5'-cAMP	-	Homo sapiens
0.0023	-	3',5'-cGMP	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	h-prune activity is suppressed by dipyridamole and enhanced by the interaction with nm23-H1. Activity is involved in promoting cancer metastasis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3',5'-cAMP + H2O	-	Homo sapiens	5'-AMP	-	?
3',5'-cGMP + H2O	-	Homo sapiens	5'-GMP	-	?
additional information	h-prune activity is suppressed by dipyridamole and enhanced by the interaction with nm23-H1. Activity is involved in promoting cancer metastasis	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
h-prune	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00078	-	IC50: 0.00078 mM	Homo sapiens	dipyridamole
0.0223	-	IC50: 0.0223 mM	Homo sapiens	vinpocetine
0.0402	-	IC50: 0.0402 mM	Homo sapiens	3-isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione

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Release 2023.1 (January 2023)